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Elevated prolactin serum levels and history of alcohol withdrawal seizures.

AbstractBACKGROUND:
Prolactin has been discussed to be useful for differential diagnosis in epilepsia. Aim of the present study was to investigate the association between prolactin serum levels and previous alcohol withdrawal seizures.
METHODS:
We assessed 118 male patients admitted for detoxification treatment. Previous withdrawal seizures were recorded and prolactin serum levels were measured using an enzymatic immunoassay.
RESULTS:
Patients with a history of alcohol withdrawal seizures had significantly higher prolactin levels (17.8 ng/ml, SD=12.1) than patients without previous seizures (13.0 ng/ml, SD=8.1, p<0.05). Logistic regression revealed significant predictive qualities for prolactin serum levels (B=0.05, Wald=5.30, p=0.021, OR=1.06, 95%CI=1.01-1.11).
CONCLUSIONS:
The present findings show an association between elevated prolactin serum levels and a history of withdrawal seizures. Hence, the results suggest that prolactin elevation at admission may be a clinical marker for an increased risk of withdrawal seizures.
AuthorsThomas Hillemacher, Kristina Bayerlein, Helge Frieling, Julia Wilhelm, Marc Ziegenbein, Johannes Kornhuber, Stefan Bleich
JournalJournal of psychiatric research (J Psychiatr Res) Vol. 41 Issue 8 Pg. 702-6 (Oct 2007) ISSN: 0022-3956 [Print] England
PMID16516235 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Biomarkers
  • Prolactin
Topics
  • Adult
  • Alcohol Withdrawal Seizures (blood, diagnosis)
  • Alcoholism (blood, rehabilitation)
  • Biomarkers (blood)
  • Diagnosis, Differential
  • Female
  • Humans
  • Logistic Models
  • Male
  • Middle Aged
  • Predictive Value of Tests
  • Prolactin (blood)
  • Prospective Studies
  • Risk Factors

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