Primary and secondary auditory cortex stimulation for intractable tinnitus.

Recent research suggests tinnitus is a phantom phenomenon based on hyperactivity of the auditory system, which can be visualized by functional neuroimaging, and transiently modulated by transcranial magnetic stimulation (TMS). We present the results of the first implanted electrodes on the primary and secondary auditory cortex after a successful TMS suppression.
Twelve patients underwent an auditory cortex implantation, 10 for unilateral and 2 for bilateral tinnitus, based on >50% suppression applying TMS. Results were analyzed for pure tone tinnitus and white noise tinnitus.
TMS results in 77% pure tone tinnitus and 67% white noise reduction. Electrical stimulation via an implanted electrode results in a mean of 97% pure tone tinnitus and 24% white noise suppression. Mean Visual Analogue Scale score decreases from 9.5 to 1.5 for pure tone and from 8.8 to 6.8 for white noise postoperatively.
Pure tone tinnitus might be the conscious percept of focal neuronal hyperactivity of the auditory cortex. Once visualized, this hyperactivity can be modulated by neurostimulation.
The preliminary results of the first implantations suggest that patients with unilateral pure tone tinnitus are good surgical candidates for electrode implantation and permanent electrical stimulation of the auditory cortex, provided that the tinnitus is of recent origin and can be suppressed by TMS.
AuthorsDirk De Ridder, Gert De Mulder, Edwin Verstraeten, Karolien Van der Kelen, Stefan Sunaert, Marion Smits, Silvia Kovacs, Jan Verlooy, Paul Van de Heyning, Aage R Moller
JournalORL; journal for oto-rhino-laryngology and its related specialties (ORL J Otorhinolaryngol Relat Spec) Vol. 68 Issue 1 Pg. 48-54; discussion 54-5 ( 2006) ISSN: 0301-1569 [Print] Switzerland
PMID16514263 (Publication Type: Journal Article)
CopyrightCopyright (c) 2006 S. Karger AG, Basel.
  • Adult
  • Auditory Cortex (physiology, physiopathology)
  • Electric Stimulation Therapy
  • Electrodes, Implanted
  • Female
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Tinnitus (etiology, physiopathology, therapy)
  • Tomography, X-Ray Computed
  • Transcranial Magnetic Stimulation

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: