Minimal deviation endometrioid adenocarcinoma of the cervix: report of three cases with exfoliative cytology.

Abstract

Three histologically confirmed minimal deviation endometrioid adenocarcinomas (MDEA) of the uterine cervix with cytologic evaluation by cervical scraping were reviewed. The smears were cellular and showed tall columnar tumor cells arranged in monolayered sheets with nuclei in palisade at free borders, rosettes, and irregular clusters. Cellular strips with palisading nuclei was noted in one case. The individual tumor cells showed monomorphic, round or oval, hyperchromatic nuclei with chromatin clumping, small nucleoli, and granular, nonvacuolated cytoplasm with cytoplasmic extensions or tails. The smear background showed a variable amount of necrotic debris admixed with polymorphonuclear leukocytes in two cases. The cytologic manifestations of those three cervical MDEAs overlapped, to some extents, with those of a cervical adenocarcinoma in situ and with those of a well-differentiated endometrial adenocarcinoma invading the cervix.

• Authors: Alexandre N Odashiro, Danilo N Odashiro, Gia-Khanh Nguyen
• Journal: Diagnostic cytopathology (Diagn Cytopathol) Vol. 34 Issue 2 Pg. 119-23 (Feb 2006) ISSN: 8755-1039 [Print] United States
• PMID: 16511847 (Publication Type: Case Reports, Journal Article)
• Copyright: 2006 Wiley-Liss, Inc.

Topics

• Adult
• Carcinoma, Endometrioid (pathology)
• Female
• Humans
• Uterine Cervical Neoplasms (pathology)