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The effect of topical retinoids on the leukotriene-B4-induced migration of polymorphonuclear leukocytes into human skin.

Abstract
Systemic retinoids are effective in a variety of inflammatory dermatoses. Disorders in which polymorphonuclear leukocytes (PMN) are involved, such as psoriasis and acne, respond particularly well to various retinoids. However, side-effects restrict the use of systemic retinoids to severe manifestations. Topical application might provide the possibility of avoiding the systemic side-effects of these compounds. In this communication we report on the modulation of transepidermal migration of PMN by topical application of all-trans-retinoic acid, 13-cis-retinoic acid, arotinoid methyl sulphone and arotinoid ethyl sulphone. Test areas of healthy volunteers were pretreated with these retinoids in a cream base and with corresponding placebo creams, and intraepidermal accumulation of PMN was quantified 24 h after epicutaneous challenge with leukotriene B4 (LTB4), using elastase as a marker enzyme. Topical treatment with 13-cis-retinoic acid resulted in a marked and statistically significant inhibition of the LTB4-induced migration of PMN. All-trans-retinoic acid, arotinoid methyl sulphone and arotinoid ethyl sulphone reduced the accumulation of PMN slightly, but not statistically significantly. Topical treatment with arotinoid methyl sulphone had no effect.
AuthorsG Wozel, A Chang, M Zultak, B M Czarnetzki, R Happle, J Barth, P C van de Kerkhof
JournalArchives of dermatological research (Arch Dermatol Res) Vol. 283 Issue 3 Pg. 158-61 ( 1991) ISSN: 0340-3696 [Print] GERMANY
PMID1651071 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article)
Chemical References
  • Retinoids
  • Leukotriene B4
Topics
  • Administration, Topical
  • Adult
  • Cell Movement (drug effects, physiology)
  • Humans
  • Leukotriene B4 (pharmacology)
  • Male
  • Neutrophils (drug effects, physiology)
  • Retinoids (administration & dosage, pharmacology)
  • Skin (cytology, drug effects)
  • Skin Physiological Phenomena

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