The effect of topical retinoids on the leukotriene-B4-induced migration of polymorphonuclear leukocytes into human skin.

Systemic retinoids are effective in a variety of inflammatory dermatoses. Disorders in which polymorphonuclear leukocytes (PMN) are involved, such as psoriasis and acne, respond particularly well to various retinoids. However, side-effects restrict the use of systemic retinoids to severe manifestations. Topical application might provide the possibility of avoiding the systemic side-effects of these compounds. In this communication we report on the modulation of transepidermal migration of PMN by topical application of all-trans-retinoic acid, 13-cis-retinoic acid, arotinoid methyl sulphone and arotinoid ethyl sulphone. Test areas of healthy volunteers were pretreated with these retinoids in a cream base and with corresponding placebo creams, and intraepidermal accumulation of PMN was quantified 24 h after epicutaneous challenge with leukotriene B4 (LTB4), using elastase as a marker enzyme. Topical treatment with 13-cis-retinoic acid resulted in a marked and statistically significant inhibition of the LTB4-induced migration of PMN. All-trans-retinoic acid, arotinoid methyl sulphone and arotinoid ethyl sulphone reduced the accumulation of PMN slightly, but not statistically significantly. Topical treatment with arotinoid methyl sulphone had no effect.
AuthorsG Wozel, A Chang, M Zultak, B M Czarnetzki, R Happle, J Barth, P C van de Kerkhof
JournalArchives of dermatological research (Arch Dermatol Res) Vol. 283 Issue 3 Pg. 158-61 ( 1991) ISSN: 0340-3696 [Print] GERMANY
PMID1651071 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article)
Chemical References
  • Retinoids
  • Leukotriene B4
  • Administration, Topical
  • Adult
  • Cell Movement (drug effects, physiology)
  • Humans
  • Leukotriene B4 (pharmacology)
  • Male
  • Neutrophils (drug effects, physiology)
  • Retinoids (administration & dosage, pharmacology)
  • Skin (cytology, drug effects)
  • Skin Physiological Phenomena

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: