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Tamoxifen improved final height prediction in a girl with McCune-Albright syndrome: patient report and literature review.

Abstract
McCune-Albright syndrome (MAS) is characterized by gonadotropin-independent precocious puberty, café-au-lait spots on the skin and polyostotic fibrous dysplasia of bones. Treatment of precocious puberty (PP) in MAS should be considered in patients with poor predicted adult height (PAH). Treatment of gonadotropin-independent PP in MAS with ketoconazole, cyproterone acetate or testolactone, an aromatase inhibitor, does not appear to be always effective in slowing bon. maturation. We report here a Thai girl with MAS who received tamoxifen, one of the selective estrogen receptor modulators, for the management of advanced puberty and rapid bone maturation. Her pubertal progression, vaginal bleeding, growth rate and PAH improved during treatment with tamoxifen despite persistently elevated serum estradiol levels and an enlarged ovarian cyst.
AuthorsPairunyar Sawathiparnich, Prapanrat Osuwanaratana, Jeerunda Santiprabhob, Supawadee Likitmaskul
JournalJournal of pediatric endocrinology & metabolism : JPEM (J Pediatr Endocrinol Metab) Vol. 19 Issue 1 Pg. 81-6 (Jan 2006) ISSN: 0334-018X [Print] Germany
PMID16509532 (Publication Type: Case Reports, Journal Article, Review)
Chemical References
  • Selective Estrogen Receptor Modulators
  • Tamoxifen
Topics
  • Body Height (drug effects)
  • Child
  • Child, Preschool
  • Female
  • Fibrous Dysplasia, Polyostotic (complications, drug therapy)
  • Humans
  • Puberty, Precocious (complications, drug therapy)
  • Selective Estrogen Receptor Modulators (therapeutic use)
  • Tamoxifen (therapeutic use)
  • Treatment Outcome

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