Abstract | BACKGROUND: METHODS: In this report, we present eight patients whose main symptom is myoclonic hyperkinesia. All patients were treated with valproic acid and scored by using the Unified Huntington's Disease Rating Scale (UHDRS) motor score before and after treatment. In addition to this, two patients agreed to be videotaped. RESULTS: In seven patients myoclonus and, therefore the UHDRS motor score improved in a dose dependent manner. In three of these patients antidopaminergic medication could be reduced. CONCLUSION: In the rare subgroup of HD patients suffering from myoclonic hyperkinesia, valproic acid is a possible alternative treatment.
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Authors | Carsten Saft, Thorsten Lauter, Peter H Kraus, Horst Przuntek, Juergen E Andrich |
Journal | BMC neurology
(BMC Neurol)
Vol. 6
Pg. 11
(Feb 28 2006)
ISSN: 1471-2377 [Electronic] England |
PMID | 16507108
(Publication Type: Clinical Trial, Comparative Study, Journal Article)
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Chemical References |
- Anticonvulsants
- Valproic Acid
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Topics |
- Adult
- Anticonvulsants
(therapeutic use)
- Dose-Response Relationship, Drug
- Female
- Humans
- Huntington Disease
(complications, drug therapy)
- Hyperkinesis
(drug therapy, etiology)
- Male
- Middle Aged
- Severity of Illness Index
- Treatment Outcome
- Valproic Acid
(therapeutic use)
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