Abstract |
The study presented here investigated the impact of initial antibiotic choice ( beta-lactams vs vancomycin) on the outcome of 342 patients with Staphylococcus aureus bacteremia (50.9% with methicillin-resistant isolates) encountered between 1 January 2002 and 30 June 2003. Initial antibiotics were inappropriate ( beta-lactams) in 60 (34.5%) methicillin-resistant cases and suboptimal ( vancomycin) in 62 (36.9%) methicillin-susceptible cases. Time to effective antibiotic therapy was longer in methicillin-resistant cases (25.5+/-28.6 vs 9.6+/-16.6 h; p<0.0005). All-cause in-hospital mortality was higher with inappropriate therapy (35.0 vs 20.9%; p=0.02). Initial vancomycin treatment was associated with a higher incidence of delayed clearance (>or=3 days) of methicillin-susceptible bacteremia (56.3 vs 37.0%; p=0.03). The results indicate inappropriate initial therapy is associated with higher in-hospital mortality and initial vancomycin may delay clearance.
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Authors | R Khatib, S Saeed, M Sharma, K Riederer, M G Fakih, L B Johnson |
Journal | European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
(Eur J Clin Microbiol Infect Dis)
Vol. 25
Issue 3
Pg. 181-5
(Mar 2006)
ISSN: 0934-9723 [Print] Germany |
PMID | 16505987
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Bacterial Agents
- beta-Lactams
- Vancomycin
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Topics |
- Adult
- Anti-Bacterial Agents
(administration & dosage, pharmacology, therapeutic use)
- Bacteremia
(drug therapy, microbiology, mortality)
- Drug Administration Schedule
- Female
- Humans
- Male
- Methicillin Resistance
- Microbial Sensitivity Tests
- Middle Aged
- Staphylococcal Infections
(drug therapy, microbiology, mortality)
- Staphylococcus aureus
(drug effects)
- Time Factors
- Treatment Outcome
- Vancomycin
(administration & dosage, pharmacology, therapeutic use)
- beta-Lactams
(administration & dosage, pharmacology, therapeutic use)
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