Abstract | PURPOSE: METHODS: We treated five LBD patients with KD and evaluated the changes in the clinical, neuropsychological and neurophysiological findings over 10-30 months. RESULTS: The KD was well tolerated in all the patients for the first 16 months. Nutritional measures and laboratory findings remained substantially stable. The disease progressed in all the patients, reaching an advanced stage in one. Electrophysiological findings indicated the presence of increased cortical excitability in four patients, paralleling the worsening of the myoclonus. CONCLUSION: KD was unable to stop the disease progression. However, given the considerable heterogeneity of the natural history of LBD, we cannot exclude the possibility that KD has the potential to slow down the disease progression. The application of this nutritional approach should be further evaluated in larger case series.
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Authors | Simonetta Cardinali, Laura Canafoglia, Simona Bertoli, Silvana Franceschetti, Giovanni Lanzi, Anna Tagliabue, Pierangelo Veggiotti |
Journal | Epilepsy research
(Epilepsy Res)
Vol. 69
Issue 2
Pg. 129-34
(May 2006)
ISSN: 0920-1211 [Print] Netherlands |
PMID | 16504479
(Publication Type: Journal Article)
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Topics |
- Adolescent
- Brain
(pathology)
- Child
- Disease Progression
- Female
- Humans
- Ketosis
- Lafora Disease
(complications, diet therapy, pathology)
- Male
- Mental Disorders
(etiology)
- Nutritional Status
- Patient Compliance
- Pilot Projects
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