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Prevention of myopia progression with 0.05% atropine solution.

AbstractAIM:
The aim of this study was to evaluate the efficacy of 0.05% atropine solution for controlling myopia progression in school-aged children.
RESULTS:
This retrospective, case-control study enrolled myopic school-aged children who had presented at Kaohsiung Chang Gung Memorial Hospital (Kaohsiung, Taiwan) from 2001 to 2004. A group of 57 children (30 boys, 27 girls; 6-12 years of age) with regular follow-up was divided into a subgroup of 21 children (12 boys, 9 girls) who received atropine eyedrops (0.05%) every evening, and a subgroup of 36 children (18 boys, 18 girls), who remained untreated, served as controls. The changes in refractive status of 114 eyes in 57 children were collected and compared for patients treated with 0.05% atropine eyedrop and those without medical control. The initial spherical equivalent of refractive status range was between -0.5 and -5.5 D. Mean myopia progression for the group of patients treated with 0.05% atropine eyedrop (n = 21) was -0.28 +/- 0.26 D/year, significantly lower than that of the control group of -0.75 +/- 0.35 D/year (36 patients; P < 0.001). The 0.05% atropine group had a significant lower ratio of uncontrolled myopia, that progressed greater than -0.50 D in 1 year, relative to the controls (16.7% versus 77.8%; P < 0.001).
CONCLUSIONS:
The results of this study demonstrate that, with regular instillation, topical 0.05% atropine is an effective agent for controlling myopia progression in a majority of school-aged children for at least a period of 1 year.
AuthorsJong-Jer Lee, Po-Chiung Fang, I-Hui Yang, Chih-Hsin Chen, Pei-Wen Lin, Sue-Ann Lin, Hsi-Kung Kuo, Pei-Chang Wu
JournalJournal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics (J Ocul Pharmacol Ther) Vol. 22 Issue 1 Pg. 41-6 (Feb 2006) ISSN: 1080-7683 [Print] United States
PMID16503774 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Mydriatics
  • Ophthalmic Solutions
  • Atropine
Topics
  • Atropine (therapeutic use)
  • Case-Control Studies
  • Child
  • Disease Progression
  • Female
  • Humans
  • Male
  • Mydriatics (therapeutic use)
  • Myopia (prevention & control)
  • Ophthalmic Solutions (therapeutic use)
  • Retrospective Studies
  • Taiwan

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