Abstract | OBJECTIVE: METHODS: A MEDLINE search (1986-August 2005) was conducted to identify pertinent studies in the English language. The search terms included pregabalin, PD144723, CI-1008, gabapentin, and neuropathic pain. Additional references were obtained from the bibliographies of identified articles. All studies that evaluated any aspect of pregabalin in vitro or in vivo in animals or humans were included, with a focus on data relevant to older adults. RESULTS: CONCLUSIONS: In the absence of active-controlled clinical trials and geriatric-specific efficacy/tolerability data, the place of pregabalin in the analgesic armamentarium for the elderly is unclear. Because pregabalin is a Schedule V controlled substance, its utility is not compromised by substantial limitation of access or the need for extra steps in prescribing. However, abuse potential is a consideration, and utilization should be carefully monitored, particularly in patients with a past or current history of substance abuse. The improved pharmacokinetic profile of pregabalin relative to gabapentin is manifested in linear and dose-independent absorption and a narrow therapeutic dosing range. However, pregabalin still requires multiple administrations per day, and daily doses > 150 mg/d require dose titration. The relatively high frequency of central nervous system adverse events, particularly dizziness and somnolence, is a concern in the elderly. Time and further experience should clarify the role of this agent.
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Authors | David R P Guay |
Journal | The American journal of geriatric pharmacotherapy
(Am J Geriatr Pharmacother)
Vol. 3
Issue 4
Pg. 274-87
(Dec 2005)
ISSN: 1543-5946 [Print] United States |
PMID | 16503325
(Publication Type: Journal Article, Review)
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Chemical References |
- Amines
- Analgesics, Non-Narcotic
- Anticonvulsants
- Cyclohexanecarboxylic Acids
- Pregabalin
- gamma-Aminobutyric Acid
- Gabapentin
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Topics |
- Aged
- Amines
(therapeutic use)
- Analgesics, Non-Narcotic
(therapeutic use)
- Anticonvulsants
(administration & dosage, adverse effects, pharmacokinetics, therapeutic use)
- Clinical Trials as Topic
- Cyclohexanecarboxylic Acids
(therapeutic use)
- Drug Interactions
- Gabapentin
- Humans
- Pain
(drug therapy, etiology)
- Peripheral Nervous System Diseases
(complications)
- Pregabalin
- gamma-Aminobutyric Acid
(administration & dosage, adverse effects, analogs & derivatives, pharmacokinetics, therapeutic use)
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