HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Prediction of breast cancer using volatile biomarkers in the breath.

Abstract
We evaluated a breath test for volatile organic compounds (VOCs) as a predictor of breast cancer. Breath VOCs were assayed in 51 asymptomatic women with abnormal mammograms and biopsy-proven breast cancer, and 42 age-matched healthy women. A fuzzy logic model predicted breast cancer with accuracy superior to previously reported findings. Following random assignment to a training set (64) or a prediction set (29), a model was constructed in the training set employing five breath VOCs that predicted breast cancer in the prediction set with 93.8% sensitivity and 84.6% specificity. The same model predicted no breast cancer in 16/50 (32.0%) women with abnormal mammograms and no cancer on biopsy. A two-minute breath test could potentially provide a safe, accurate and painless screening test for breast cancer, but prospective validation studies are required.
AuthorsMichael Phillips, Renee N Cataneo, Beth Ann Ditkoff, Peter Fisher, Joel Greenberg, Ratnasiri Gunawardena, C Stephan Kwon, Olaf Tietje, Cynthia Wong
JournalBreast cancer research and treatment (Breast Cancer Res Treat) Vol. 99 Issue 1 Pg. 19-21 (Sep 2006) ISSN: 0167-6806 [Print] Netherlands
PMID16502014 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)
Chemical References
  • Biomarkers, Tumor
  • Organic Chemicals
Topics
  • Age Factors
  • Aged
  • Biomarkers, Tumor (metabolism)
  • Biopsy
  • Breast Neoplasms (diagnosis, metabolism)
  • Breath Tests
  • Case-Control Studies
  • Female
  • Fuzzy Logic
  • Humans
  • Middle Aged
  • Models, Statistical
  • Organic Chemicals
  • Prospective Studies
  • Sensitivity and Specificity

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: