Higher incidence of chemotherapy induced oral mucositis in females: a supplement of multivariate analysis to a randomized multicentre study.

Abstract

Study on the normal saline vs povidone-iodine mouthwashes for oral mucositis (OM) prophylaxis in patients after high-dose chemotherapy comprising bischloroethyl nitrosourea etoposide ara-C melphalan (BEAM) or high-dose melphalan (HD-L-PAM) followed by autologous peripheral stem cell transplantation indicated that females have higher a incidence of OM compared to men, as reported by [Vokurka et al. 13:554-558, (2005)]. The multivariable analysis of larger cohort of 148 patients compliant with the original study protocol confirmed female gender to be an independent risk factor and predictor for OM. The HD-L-PAM (200 mg/m2) conditioning regimen revealed to be more toxic compared to BEAM as for incidence of OM grades 3-4 World Health Organization score. Body mass index, age, mouthwash solution used, and CD34+ cell number in the autologous graft were verified not to have an impact on OM incidence in this group of patients.

• Authors: Samuel Vokurka, Eva Bystrická, Vladimír Koza, Jana Scudlová, Vladislava Pavlicová, Dana Valentová, Maria Visokaiová, Lubica Misaniová
• Journal: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer (Support Care Cancer) Vol. 14 Issue 9 Pg. 974-6 (Sep 2006) ISSN: 0941-4355 [Print] Germany
• PMID: 16502004 (Publication Type: Journal Article)

Chemical References

• Cytarabine
• Etoposide
• Melphalan
• Carmustine

Topics

• Adolescent
• Adult
• Aged
• Analysis of Variance
• Antineoplastic Combined Chemotherapy Protocols (administration & dosage, adverse effects)
• Carmustine (administration & dosage, adverse effects)
• Cytarabine (administration & dosage, adverse effects)
• Etoposide (administration & dosage, adverse effects)
• Female
• Humans
• Incidence
• Male
• Melphalan (administration & dosage, adverse effects)
• Middle Aged
• Multicenter Studies as Topic
• Multivariate Analysis
• Oral Ulcer (chemically induced, epidemiology)
• Peripheral Blood Stem Cell Transplantation
• Predictive Value of Tests
• Randomized Controlled Trials as Topic
• Risk Factors
• Severity of Illness Index
• Sex Factors
• Stomatitis (chemically induced, epidemiology)
• Transplantation, Autologous