HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Multimodal immunosuppressant therapy in steroid-refractory common variable immunodeficiency sprue: a case report complicating cytomegalovirus infection.

Abstract
Immunodeficient patients can develop malabsorption, mimicking celiac disease clinically and histologically. Such individuals may also occasionally require immunosuppressive therapy for autoimmune disorders. We have identified a patient with common variable immunodeficiency (CVID)-associated sprue complicated by duodenal cytomegalovirus (CMV) infection following corticosteroid and ancillary immunomodulatory therapy. Ganciclovir and a modification of the immunosuppressant regimen improved both clinical symptoms and villous atrophy. To our knowledge, this is original documentation of duodenal CMV infection secondary to immunomodulatory therapy for steroid-refractory CVID-sprue.
AuthorsS A C Medlicott, S Coderre, G Horne, R Panaccione
JournalInternational journal of surgical pathology (Int J Surg Pathol) Vol. 14 Issue 1 Pg. 101-6 (Jan 2006) ISSN: 1066-8969 [Print] United States
PMID16501846 (Publication Type: Case Reports, Journal Article)
CopyrightInt J Surg Pathol 14(1):101-106, 2006.
Chemical References
  • Adrenal Cortex Hormones
  • Antibodies, Monoclonal
  • Antiviral Agents
  • Immunologic Factors
  • Immunosuppressive Agents
  • Steroids
  • Infliximab
  • Azathioprine
  • Ganciclovir
  • Prednisone
Topics
  • Adrenal Cortex Hormones (therapeutic use)
  • Antibodies, Monoclonal (therapeutic use)
  • Antiviral Agents (therapeutic use)
  • Azathioprine (therapeutic use)
  • Celiac Disease (complications, diagnosis, drug therapy)
  • Common Variable Immunodeficiency (complications, diagnosis, drug therapy)
  • Cytomegalovirus (isolation & purification)
  • Cytomegalovirus Infections (complications, diagnosis, drug therapy)
  • Diagnosis, Differential
  • Drug Resistance
  • Duodenum (drug effects, pathology, virology)
  • Female
  • Ganciclovir (therapeutic use)
  • Humans
  • Immunologic Factors (therapeutic use)
  • Immunosuppressive Agents (therapeutic use)
  • Infliximab
  • Lymphoma, T-Cell (diagnosis, etiology, pathology)
  • Middle Aged
  • Prednisone (therapeutic use)
  • Steroids (therapeutic use)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: