To study the changes in the epidemiology, clinical and bacteriological profiles of
bacterial meningitis in the era of the Haemophilus influenzae type b (Hib)vaccine and pneumococcus resistance.
METHODS: This is a retrospective study of children aged <12 years admitted to the Hamad Medical Corporation, Qatar between January 1998 through December 2002 with positive cerebrospinal fluid culture.
RESULTS: We described 64 patients with culture proven
bacterial meningitis. In infants <3 months (n=29 [45%]), the most common organism was Group B Streptococcus (GBS) (20%). Children >3 months (n=35 [55%]); Hib (25%) and Streptococcus pneumoniae (STP) (20%) were the most common organisms before introduction of Hib vaccination. A significant drop of
Hib infections were noticed after introduction of the
vaccine.
Fever, neck stiffness, seizure,
vomiting, and bulging fontanel were the most frequent presenting features. Group B Streptococcus were sensitive to
ampicillin and
cefotaxime with no resistance detected. Forty percent of STP isolates were resistant to
penicillin and 12% were resistant to
ceftriaxone. Fifty percent of Hib were resistant to
ampicillin; while none of Hib were resistant to
ceftriaxone. No case of
Listeria monocytogenes meningitis was diagnosed. Morbidity was 28%, and one patient expired (2%) after Klebsiella pneumoniae
meningitis. Streptococcus pneumoniae was associated with the highest morbidity (62%) while Hib had zero morbidity in our patients.
CONCLUSION: