Abstract | PURPOSE: METHODS: Twenty children were treated prospectively in a hospital-based ambulatory clinic from September 2003 to May 2005. Children aged 3-18 years, with at least three seizures per week, who had been treated with at least two anticonvulsants, were enrolled and received the diet over a 6-month period. Carbohydrates were initially limited to 10 g/day, and fats were encouraged. Parents measured urinary ketones semiweekly and recorded seizures daily. All children received vitamin and calcium supplementation. RESULTS: In all children, at least moderate urinary ketosis developed within 4 days (mean, 1.9). Sixteen (80%) completed the 6-month study; 14 chose to remain on the diet afterward. At 6 months, 13 (65%) had >50% improvement, and seven (35%) had >90% improvement (four were seizure free). Mean seizure frequency after 6 months was 40 per week (p = 0.005). Over a 6-month period, mean serum blood urea nitrogen increased from 12 to 17 mg/dl (p = 0.01); creatinine was unchanged. Cholesterol increased from 192 to 221 mg/dl, (p = 0.06). Weight did not change significantly (34.0-33.7 kg); only six children lost weight. A stable body mass index over time correlated with >90% improvement (p = 0.004). CONCLUSIONS:
|
Authors | Eric H Kossoff, Jane R McGrogan, Renee M Bluml, Diana J Pillas, James E Rubenstein, Eileen P Vining |
Journal | Epilepsia
(Epilepsia)
Vol. 47
Issue 2
Pg. 421-4
(Feb 2006)
ISSN: 0013-9580 [Print] United States |
PMID | 16499770
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Anticonvulsants
- Dietary Fats
- Dietary Proteins
- Ketones
- Cholesterol
- Creatinine
- Nitrogen
|
Topics |
- Adolescent
- Age Factors
- Anticonvulsants
(therapeutic use)
- Blood Urea Nitrogen
- Child
- Child, Preschool
- Cholesterol
(blood)
- Creatinine
(blood)
- Diet, Carbohydrate-Restricted
(methods)
- Dietary Fats
(administration & dosage, metabolism)
- Dietary Proteins
(administration & dosage, metabolism)
- Epilepsy
(blood, diet therapy, metabolism)
- Female
- Follow-Up Studies
- Humans
- Ketones
(urine)
- Ketosis
(blood, etiology, urine)
- Male
- Nitrogen
(blood)
- Treatment Outcome
- Weight Loss
|