[Synthesis, structure characterization and anti-tumor activity of lanthanide complex Ln[ (Phen)2 (5-Fu)3 (NO3) (NO3 )2].

Abstract

AIM:

To study the biochemistry of lanthanides, the cooperative action of inorganic and organic anti-tumor drugs.

METHODS:

A series of rare earth complexes were synthesized with Ln(NO3) 6H2O, Phen and 5-Fu. Their anti-tumor activity was measured by the improved MTT, SRB methods.

RESULTS:

The formula of complex Ln[(Phen)2(5-Fu)3(NO3)](NO3)2(Ln = Y, La, Ce, Sm, Gd, Dy, Er; Phen = 1, 10-phenanthroline; 5-Fu = fluorouracil) was characterized by elemental analyses, molar conductivity, IR, TGA, and 13C NMR spectra. The preliminary biological activity studies indicated that Lanthanide complex has strong anti-tumor activity in vitro.

CONCLUSION:

The complex might have anti-tumor cooperation action.

• Authors: Wen-yuan Zhong, Zhi-xing Hu, Shun-fang Chen, Shu-yu Ji, Yi-ping Zhou, Ma-lin Li
• Journal: Yao xue xue bao = Acta pharmaceutica Sinica (Yao Xue Xue Bao) Vol. 40 Issue 11 Pg. 997-1000 (Nov 2005) ISSN: 0513-4870 [Print] China
• PMID: 16499083 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Lanthanoid Series Elements
• Phenanthrolines
• Dysprosium
• Cerium
• Samarium
• Yttrium
• Lanthanum
• Erbium
• Gadolinium
• Fluorouracil

Topics

• Antineoplastic Agents (chemical synthesis, chemistry, pharmacology)
• Cell Line, Tumor
• Cell Proliferation (drug effects)
• Cerium (chemistry)
• Drug Synergism
• Dysprosium (chemistry)
• Erbium (chemistry)
• Fluorouracil (chemistry)
• Gadolinium (chemistry)
• Humans
• Lanthanoid Series Elements (chemistry)
• Lanthanum (chemistry)
• Phenanthrolines (chemistry)
• Samarium (chemistry)
• Structure-Activity Relationship
• Yttrium (chemistry)