Abstract |
Determining the cause of Cushing's disease and correcting the abnormality presents a continuing challenge to the clinician despite remarkable advances in diagnostic and therapeutic techniques. We present seven cases to illustrate 1) the classic disorder cured by pituitary adenomectomy; 2) persistence of the disease after adenomectomy; 3) Cushing's disease manifesting in the puerperium and remitting with dopamine agonist therapy; 4) a patient whose disease relapsed at least five times during 20 years of treatment by adrenalectomy, pituitary radiation, mitotane, and pituitary adenomectomy; 5) the Nelson syndrome; 6) the ectopic adrenocorticotropic hormone ( ACTH) syndrome in a patient with dexamethasone suppressible urinary cortisol who had a pituitary adenoma which stained positively for ACTH but who was not cured by total hypophysectomy; and 7) a patient whose ACTH-secreting tumor proved fatal despite repeated surgical, radiologic and pharmacologic measures.
|
Authors | M Saeed-uz-Zafar, R C Mellinger, M Wisgerhof |
Journal | Henry Ford Hospital medical journal
(Henry Ford Hosp Med J)
Vol. 39
Issue 1
Pg. 10-7
( 1991)
ISSN: 0018-0416 [Print] United States |
PMID | 1649807
(Publication Type: Case Reports, Journal Article)
|
Chemical References |
- Adrenocorticotropic Hormone
|
Topics |
- Adrenocorticotropic Hormone
(blood)
- Adult
- Aged
- Cushing Syndrome
(blood, complications, diagnosis, therapy)
- Female
- Humans
- Hypophysectomy
- Male
- Nelson Syndrome
(etiology)
- Puerperal Disorders
(diagnosis)
- Recurrence
|