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[Effects of dipfluzine on expressions of E-selectin, P-selectin, and ICAM-1 in brain ischemia-reperfusion rats].

AbstractAIM:
To evaluate the effects of dipfluzine on the expressions of E-selectin, P-selectin, and ICAM-1 and the infiltration of polymorphonuclear leukocytes in brain ischemia-reperfusion rats.
METHODS:
The model of focal cerebral ischemia was established with the Zea-Longa occluding suture. Dipfluzine (0.25, 0.5 and 1 mg x kg(-1)), flunarizine 0.5 mg x kg(-1) and solvent were injected separately into lingual vein at 30 min after ischemia. The occluding suture was slowly taken away to cause reperfusion at 1 h after ischemia. Rats were decapitated under anesthesia at 24 h after ischemia-reperfusion and brains were immediately removed to do the following procedures. Effects of dipfluzine on morphology of the brain tissue were observed through hematoxylin-eosin (HE) staining. By immunohistochemistry and flow cytometry technique and biochemical method, effects of dipfluzine on P-selectin, E-selectin, ICAM-1 and myeloperoxidase (MPO) were observed.
RESULTS:
Dipfluzine could relieve pathological damages in the brain tissue after ischemia-reperfusion, and reduce the expressions of E-selectin, P-selectin and ICAM-1 and activities of MPO in dose-dependent manner.
CONCLUSION:
Dipfluzine depresses the expressions of P-selectin, E-selectin, and ICAM-1, which are correlated with their effects on the activities of MPO, suggesting that dipfluzine has anti-inflammation effect in certain extent and could protect brain tissue from ischemia-reperfusion injury.
AuthorsGuo-hong Zhang, Ping Lü, Yong-li Wang
JournalYao xue xue bao = Acta pharmaceutica Sinica (Yao Xue Xue Bao) Vol. 40 Issue 12 Pg. 1091-5 (Dec 2005) ISSN: 0513-4870 [Print] China
PMID16496671 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • E-Selectin
  • Neuroprotective Agents
  • P-Selectin
  • Intercellular Adhesion Molecule-1
  • Cinnarizine
  • dipfluzine
  • Peroxidase
Topics
  • Animals
  • Brain Ischemia (etiology)
  • Cerebral Cortex (metabolism, pathology)
  • Cinnarizine (administration & dosage, analogs & derivatives, pharmacology)
  • Dose-Response Relationship, Drug
  • E-Selectin (metabolism)
  • Infarction, Middle Cerebral Artery (complications)
  • Intercellular Adhesion Molecule-1 (metabolism)
  • Male
  • Neuroprotective Agents (administration & dosage, pharmacology)
  • P-Selectin (metabolism)
  • Peroxidase (metabolism)
  • Rats
  • Rats, Sprague-Dawley
  • Reperfusion Injury (etiology, metabolism, pathology)

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