Abstract | BACKGROUND: METHODS: RESULTS: The protein and mRNA levels of matriptase were significantly higher in all carcinoma cells as compared with NHPE cells. Conversely, all CaP cells exhibited a reduced expression of HAI-1 as compared with NHPE cells. A progressive increase in the protein levels of matriptase was observed with increasing tumor grade in CaP specimens as compared with normal and BPH tissue specimens. Tissue samples of normal prostate exhibited a high constitutive protein level of HAI-1 compared with BPH and low-grade cancer with a progressive loss with increasing tumor grade. CONCLUSION: The increased expression of matriptase and loss of HAI-1 may be an important event during the progression of CaP in humans. We suggest that the ratio of these two gene products may serve as a promising biomarker for CaP progression and a potential marker for establishing the efficacy of therapeutic and chemopreventive interventions.
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Authors | Mohammad Saleem, Vaqar Mustafa Adhami, Weixiong Zhong, B Jack Longley, Chen-Yong Lin, Robert B Dickson, Shannon Reagan-Shaw, David F Jarrard, Hasan Mukhtar |
Journal | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
(Cancer Epidemiol Biomarkers Prev)
Vol. 15
Issue 2
Pg. 217-27
(Feb 2006)
ISSN: 1055-9965 [Print] United States |
PMID | 16492908
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers, Tumor
- Membrane Glycoproteins
- Proteinase Inhibitory Proteins, Secretory
- RNA, Messenger
- SPINT1 protein, human
- Serine Endopeptidases
- matriptase
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Topics |
- Adenocarcinoma
(metabolism, pathology)
- Biomarkers, Tumor
(metabolism)
- Disease Progression
- Epithelial Cells
(metabolism)
- Humans
- Male
- Membrane Glycoproteins
(metabolism)
- Neoplasm Staging
(methods)
- Prostatic Neoplasms
(metabolism, pathology)
- Proteinase Inhibitory Proteins, Secretory
- RNA, Messenger
(metabolism)
- Serine Endopeptidases
(metabolism)
- Tumor Cells, Cultured
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