On a possible protective effect of HLA-A11 against skin cancer and keratotic skin lesions in renal transplant recipients.

Abstract

Renal transplant recipients who have skin cancer potentially related to human papillomavirus were HLA typed with a special focus on HLA-A11, which in nonimmunosuppressed patients is negatively associated with the occurrence of virus-related carcinoma of the cervix. We found also a negative association between HLA-A11 and skin cancer; none of the 66 transplant recipients with skin cancer were positive for HLA-A11. As HLA-A11 seems to have a protective effect against skin cancer, we speculate that antigens induced by squamous cell carcinomas and possibly also by human papillomavirus may be efficiently presented through HLA-A11 to cytotoxic T cells. We also investigated a possible influence of other HLA alleles on the susceptibility of renal transplant recipients to skin cancer. The frequency of HLA-B27 was significantly higher in the transplant recipients with skin cancer, with a relative risk of 3.4 relative to healthy controls. No significant differences were found for other HLA class I or class II antigens.

• Authors: J N Bouwes Bavinck, A M Kootte, F J Van Der Woude, J P Vandenbroucke, B J Vermeer, F H Claas
• Journal: The Journal of investigative dermatology (J Invest Dermatol) Vol. 97 Issue 2 Pg. 269-72 (Aug 1991) ISSN: 0022-202X [Print] United States
• PMID: 1649229 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• HLA-A Antigens
• HLA-A11 Antigen

Topics

• Alleles
• Carcinoma, Basal Cell (immunology, microbiology)
• Carcinoma, Squamous Cell (immunology, microbiology)
• HLA-A Antigens (genetics, immunology)
• HLA-A11 Antigen
• Humans
• Keratosis (immunology, microbiology)
• Kidney Transplantation (immunology, physiology)
• Papillomaviridae
• Skin Neoplasms (immunology, microbiology)