Abstract |
Renal transplant recipients who have skin cancer potentially related to human papillomavirus were HLA typed with a special focus on HLA-A11, which in nonimmunosuppressed patients is negatively associated with the occurrence of virus-related carcinoma of the cervix. We found also a negative association between HLA-A11 and skin cancer; none of the 66 transplant recipients with skin cancer were positive for HLA-A11. As HLA-A11 seems to have a protective effect against skin cancer, we speculate that antigens induced by squamous cell carcinomas and possibly also by human papillomavirus may be efficiently presented through HLA-A11 to cytotoxic T cells. We also investigated a possible influence of other HLA alleles on the susceptibility of renal transplant recipients to skin cancer. The frequency of HLA-B27 was significantly higher in the transplant recipients with skin cancer, with a relative risk of 3.4 relative to healthy controls. No significant differences were found for other HLA class I or class II antigens.
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Authors | J N Bouwes Bavinck, A M Kootte, F J Van Der Woude, J P Vandenbroucke, B J Vermeer, F H Claas |
Journal | The Journal of investigative dermatology
(J Invest Dermatol)
Vol. 97
Issue 2
Pg. 269-72
(Aug 1991)
ISSN: 0022-202X [Print] United States |
PMID | 1649229
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- HLA-A Antigens
- HLA-A11 Antigen
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Topics |
- Alleles
- Carcinoma, Basal Cell
(immunology, microbiology)
- Carcinoma, Squamous Cell
(immunology, microbiology)
- HLA-A Antigens
(genetics, immunology)
- HLA-A11 Antigen
- Humans
- Keratosis
(immunology, microbiology)
- Kidney Transplantation
(immunology, physiology)
- Papillomaviridae
- Skin Neoplasms
(immunology, microbiology)
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