Drug challenge test (DCT) is performed to evaluate
chronic pain pharmacologically and determine its medical treatment. One test
drug is administered in one day for DCT and characterization of the test
drug. Four patients developed side effects of the test drugs for DCT in whom other
drug tests were postponed or canceled. A 58-year-old man with multiple
arthritis of
rheumatic arthritis and
fibromyalgia had
headache,
nausea, and
vomiting all day after
ketamine test. A 76-year-old man with chronic general
pain and
failed back surgery syndrome had
vomiting and abdominal discomfort two hours after
morphine test and had redness and
itching on his bilateral forearms the following day. A 78-year-old man with chronic lumbar and right lower limb
pain due to L 4-5 lumbar
disc herniation and
postherpetic neuralgia felt dizzy, fell down and bruised on his lower back and left knee twelve hours after
morphine test. A 32-year-old woman with chronic
pelvic pain had skin eruption on her thigh the day after
phentolamine test. Although the amount of the test
drug in DCT is small and its half-life is short, long-term side effects might occur. We should decrease the amounts or frequencies of
ketamine and
morphine, and administer them taking long intervals before other tests.