Abstract | BACKGROUND: METHODS: Male Wistar rats were divided into six groups: I/R + BIAP, I/R + saline, I/R + PHX + BIAP and I/R + PHX + saline, PHX only or sham laparotomy only. A single dose of BIAP (0.5 units/g) or vehicle (saline) was administered 5 min before reperfusion. Inflammatory response, and hepatic and pulmonary injury were assessed during 24 h of reperfusion. RESULTS: I/R, with or without PHX, increased all markers of inflammation, and hepatic and pulmonary damage (P < 0.050 versus sham operation). I/R + PHX significantly increased release of aspartate aminotransferase (AST) and alanine aminotransferase (ALT), and hepatic neutrophil influx compared with I/R only (P < 0.050). BIAP treatment decreased hepatic wet/dry ratios, neutrophil influx and histopathological damage after I/R with or without PHX (P < 0.050), and also AST, ALT and interleukin (IL)-6 production after I/R + PHX (P < 0.050). BIAP treatment reduced the neutrophil influx after I/R, and pulmonary histopathological injury was decreased after I/R with or without PHX. CONCLUSION:
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Authors | S Q van Veen, S Dinant, A K van Vliet, T M van Gulik |
Journal | The British journal of surgery
(Br J Surg)
Vol. 93
Issue 4
Pg. 448-56
(Apr 2006)
ISSN: 0007-1323 [Print] England |
PMID | 16491472
(Publication Type: Journal Article)
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Chemical References |
- Cytokines
- Alkaline Phosphatase
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Topics |
- Alkaline Phosphatase
(therapeutic use)
- Analysis of Variance
- Animals
- Cytokines
(metabolism)
- Hepatectomy
(methods)
- Ischemia
(drug therapy)
- Ligation
(methods)
- Liver
(blood supply, surgery)
- Liver Cirrhosis
(pathology)
- Lung
(blood supply)
- Male
- Pneumonia
(pathology)
- Rats
- Rats, Wistar
- Reperfusion
- Reperfusion Injury
(pathology, prevention & control)
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