Topical ibopamine in the treatment of chronic ocular hypotony attributable to vitreoretinal surgery, uveitis, or penetrating trauma.

Abstract

PURPOSE:

To study whether topical ibopamine effectively increases the intraocular pressure in patients with ocular hypotony after vitreoretinal surgery, uveitis, or penetrating trauma.

DESIGN:

A prospective randomized, double-blind, placebo controlled, crossover study.

METHODS:

In ten patients with ocular hypotony, an ibopamine 2% solution or placebo eyedrop was administered at 8 am and frequent applanation tonometry was performed during 10 hours on 2 days, 2 weeks apart.

RESULTS:

The mean IOP integral after administration of ibopamine was 2.4 mm Hg higher (95% CI for median difference in AUC over 480 minutes [P = .010]) compared with placebo.

CONCLUSIONS:

The results of the study show that an ibopamine 2% eyedrop twice a day may increase the IOP for a period of over 8 hours in patients with hypotony.

• Authors: Luana Cahya Ugahary, Elisabeth Ganteris, Marc Veckeneer, Adam C Cohen, Jan Jansen, Paul G H Mulder, Jan C van Meurs
• Journal: American journal of ophthalmology (Am J Ophthalmol) Vol. 141 Issue 3 Pg. 571-3 (Mar 2006) ISSN: 0002-9394 [Print] United States
• PMID: 16490513 (Publication Type: Journal Article, Randomized Controlled Trial)

Chemical References

• Dopamine Agonists
• ibopamine
• Deoxyepinephrine

Topics

• Administration, Topical
• Adult
• Aged
• Chronic Disease
• Cross-Over Studies
• Deoxyepinephrine (administration & dosage, analogs & derivatives, therapeutic use)
• Dopamine Agonists (administration & dosage, therapeutic use)
• Double-Blind Method
• Eye Injuries, Penetrating (complications)
• Female
• Humans
• Intraocular Pressure (drug effects)
• Male
• Middle Aged
• Ocular Hypotension (drug therapy, etiology)
• Prospective Studies
• Tonometry, Ocular
• Uveitis (complications)
• Visual Acuity
• Vitrectomy (adverse effects)