Carcinogenicity of dinitropyrenes in the weanling female CD rat.

Abstract

The carcinogenicities of 1-nitropyrene and 1,3-, 1,6- and 1,8-dinitropyrene were assessed in weanling female CD rats. The animals were administered one of the compounds at 10 mumol/kg body wt through intraperitoneal or intragastric administration three times a week for 4 weeks. The total cumulative dose averaged 16 mumol/animal. The experiment was ended 78 weeks following the first administration. The average survival period for the animals in the 1,6- and 1,8-dinitropyrene i.p. treated groups, due to the occurrence of life-threatening peritoneal malignant fibrous histiocytomas (MFHs) in nearly all of the animals, were 19 and 38 weeks respectively. 1,3-Dinitropyrene induced only a few MFHs. 1,8-Dinitropyrene also induced a significant incidence of leukemia. A significant increase of the incidence of mammary tumors was observed in the groups of rats treated i.p. with 1-nitropyrene, or 1,3- or 1,8-dinitropyrene, and those treated i.g. with 1,8-dinitropyrene. These results demonstrate that nitropyrenes are capable of inducing MFH, mammary tumors and leukemia in the rat.

• Authors: K Imaida, M S Lee, C Y Wang, C M King
• Journal: Carcinogenesis (Carcinogenesis) Vol. 12 Issue 7 Pg. 1187-91 (Jul 1991) ISSN: 0143-3334 [Print] England
• PMID: 1649014 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Carcinogens
• Pyrenes
• 1,8-dinitropyrene
• 1,6-dinitropyrene
• 1,3-dinitropyrene
• 1-nitropyrene

Topics

• Adenocarcinoma (chemically induced)
• Adenofibroma (chemically induced)
• Animals
• Carcinogens
• Female
• Histiocytoma, Benign Fibrous (chemically induced)
• Leukemia, Experimental (chemically induced)
• Mammary Neoplasms, Experimental (chemically induced)
• Pyrenes (administration & dosage, toxicity)
• Rats
• Rats, Inbred Strains