Systemic contact dermatitis after oral exposure to nickel: a review with a modified meta-analysis.

Abstract

Systemic contact dermatitis can be elicited experimentally in nickel-sensitive individuals by oral nickel exposure. A crucial point interpreting such experiments has been the relevance of nickel exposure from drinking water and diet. The aim of this meta-analysis study on former nickel-exposure investigations was to provide the best possible estimation of threshold values of nickel doses that may cause systemic contact dermatitis in nickel-sensitive patients. 17 relevant investigations were identified, and statistical analyses were performed in a stepwise procedure. 9 studies were included in the final dose-response analysis, which divided the studies into a homogenous middle group of 5 studies and 2 groups of 2 studies with a higher and lower response frequency, respectively, described by logistic dose-response curves shifted in parallel. On the basis of these curves, calculations were made of the doses that, theoretically, would cause systemic contact dermatitis in exposed nickel-sensitive patients. The results from the 2 most sensitive groups show that 1% of these individuals may react with systemic contact dermatitis at normal daily nickel exposure from drinking water and diet, i.e. 0.22-0.35 mg nickel.

• Authors: Christian Stab Jensen, Torkil Menné, Jeanne Duus Johansen
• Journal: Contact dermatitis (Contact Dermatitis) Vol. 54 Issue 2 Pg. 79-86 (Feb 2006) ISSN: 0105-1873 [Print] England
• PMID: 16487279 (Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't)

Chemical References

• Allergens
• Nickel

Topics

• Administration, Oral
• Allergens (administration & dosage)
• Dermatitis, Allergic Contact (diagnosis, etiology, pathology)
• Dose-Response Relationship, Drug
• Food
• Humans
• Nickel (administration & dosage)
• Patch Tests (statistics & numerical data)
• Water Supply