Goat milk oligosaccharides are anti-inflammatory in rats with hapten-induced colitis.

Abstract

Oligosaccharides are included among the anti-inflammatory components of milk because of their prebiotic properties and their capacity to act as receptors of microorganisms. Here the intestinal anti-inflammatory effect of goat milk oligosaccharides (O) was assessed in trinitrobenzenesulfonic (T) acid-induced colitis in rats. Rats were randomly assigned to three different groups. Two groups (T and OS) of colitic rats and a control group (C) were studied. Group OS received 500 mg/(kg.d) of goat milk oligosaccharides orally, starting 2 d before the colitis induction until d 6, and groups T and C received the vehicle. When compared with the T group, the OS group showed decreased anorexia and body weight loss; reduced bowel wall thickening and longitudinal extension of necrotic lesions; downregulated colonic expression of interleukin 1beta, inducible nitric oxide synthase, cyclooxygenase 2, and mucin 3; and increased trefoil factor 3. Thus, goat milk oligosaccharides have anti-inflammatory effects in rats with experimental colitis and may be useful in the management of inflammatory bowel disease.

• Authors: Abdelali Daddaoua, Victor Puerta, Pilar Requena, Antonio Martínez-Férez, Emilia Guadix, Fermín Sánchez de Medina, Antonio Zarzuelo, María Dolores Suárez, Julio José Boza, Olga Martínez-Augustin
• Journal: The Journal of nutrition (J Nutr) Vol. 136 Issue 3 Pg. 672-6 (Mar 2006) ISSN: 0022-3166 [Print] United States
• PMID: 16484541 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Inflammatory Agents
• Haptens
• Interleukin-1
• Muc3 protein, rat
• Mucin-3
• Mucins
• Oligosaccharides
• Nitric Oxide Synthase Type II
• Cyclooxygenase 2

Topics

• Animals
• Anti-Inflammatory Agents (pharmacology)
• Colitis (chemically induced, immunology)
• Colon (drug effects, immunology, pathology)
• Cyclooxygenase 2 (genetics)
• Gene Expression Regulation (drug effects)
• Goats
• Haptens
• Interleukin-1 (genetics)
• Milk (chemistry)
• Mucin-3
• Mucins (genetics)
• Nitric Oxide Synthase Type II (genetics)
• Oligosaccharides (isolation & purification, pharmacology)
• Rats