Modulation of delta opioid-evoked hypothermia in rats by WAY 100635 and fluoxetine.

Abstract

Delta opioid receptor and 5-hydroxytryptamine (5-HT) interactions in rats were investigated using the endpoint of hypothermia. The intraperitoneal (i.p.) administration of SNC-80, a delta opioid agonist (35 mg/kg, i.p.), produced a significant hypothermia. For combined administration, SNC-80-evoked hypothermia was (1) abolished by pre-treatment with naltrindole (5 mg/kg, i.p.); (2) attenuated by pre-treatment with WAY 100635 (1 mg/kg, s.c.), a 5-HT1A antagonist; and (3) enhanced by pre-treatment with non-hypothermic doses of fluoxetine (2.5, 5 and 10 mg/kg, i.p.). The present data reveal that 5-HT1A receptor activation mediates a significant proportion of the hypothermic response to delta opioid receptor activation and that a 5-HT uptake blockade potentiates delta receptor-induced hypothermia.

• Authors: Scott M Rawls, Alan Cowan
• Journal: Neuroscience letters (Neurosci Lett) Vol. 398 Issue 3 Pg. 319-24 (May 08 2006) ISSN: 0304-3940 [Print] Ireland
• PMID: 16483716 (Publication Type: Journal Article)

Chemical References

• Benzamides
• Piperazines
• Pyridines
• Receptors, Opioid, delta
• Serotonin 5-HT1 Receptor Antagonists
• Serotonin Uptake Inhibitors
• Fluoxetine
• Receptor, Serotonin, 5-HT1A
• 4-(alpha-(4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl)-N,N-diethylbenzamide
• N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide

Topics

• Animals
• Benzamides (pharmacology)
• Body Temperature Regulation
• Fluoxetine (pharmacology)
• Hypothermia (metabolism, physiopathology)
• Male
• Piperazines (pharmacology)
• Pyridines (pharmacology)
• Rats
• Rats, Sprague-Dawley
• Receptor, Serotonin, 5-HT1A (physiology)
• Receptors, Opioid, delta (agonists, physiology)
• Serotonin 5-HT1 Receptor Antagonists
• Selective Serotonin Reuptake Inhibitors (pharmacology)