HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Serotonin transporter gene promoter polymorphism and autism: a family-based genetic association study in Japanese population.

Abstract
Autism is now widely accepted as a biological disorder which, by and large, starts before birth. It has been shown that serotonin (5-HT) is associated with several psychological processes and hyperserotoninemia is observed in some autistic patients. The results of previous reports about family-based association studies between the serotonin transporter (5-HTT) gene promoter polymorphism and autism are controversial. In this study, an analysis using the transmission/disequilibrium test (TDT) between the 5-HTT gene promoter polymorphism and autism in 104 trios, all ethnically Japanese, showed no significant linkage disequilibrium (P=0.17). Recently, it has been reported that some haplotypes at the serotonin transporter locus may be associated with the pathogenesis of autism. Therefore, further investigations by haplotype analyses are necessary to confirm the implications of genetic variants of the serotonin transporter in the etiology of autism.
AuthorsShinko Koishi, Kenji Yamamoto, Hideo Matsumoto, Seiji Koishi, Youichi Enseki, Akitoshi Oya, Arata Asakura, Yutaka Aoki, Mariko Atsumi, Tomiei Iga, Jyoji Inomata, Hidetoshi Inoko, Tsukasa Sasaki, Eiji Nanba, Nobumasa Kato, Tetsuo Ishii, Kosuke Yamazaki
JournalBrain & development (Brain Dev) Vol. 28 Issue 4 Pg. 257-60 (May 2006) ISSN: 0387-7604 [Print] Netherlands
PMID16481140 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Serotonin Plasma Membrane Transport Proteins
  • Serotonin
Topics
  • Adolescent
  • Adult
  • Autistic Disorder (ethnology, genetics, metabolism)
  • Brain (metabolism, physiopathology)
  • Brain Chemistry (genetics)
  • DNA Mutational Analysis
  • Female
  • Genetic Predisposition to Disease (genetics)
  • Genetic Testing
  • Humans
  • Japan
  • Male
  • Middle Aged
  • Mutation (genetics)
  • Polymorphism, Genetic (genetics)
  • Promoter Regions, Genetic (genetics)
  • Serotonin (metabolism)
  • Serotonin Plasma Membrane Transport Proteins (genetics)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: