Abstract |
A mitochondria-targeted antioxidant, Mito Vitamin E ( MitoVit E), has previously been shown to prevent mitochondrial oxidative damage. The aim of this study was to investigate the effect of MitoVit E on neuronal survival in the rat striatum after acute perinatal hypoxia- ischemia. Continuous striatal infusion with 4.35 microM, 43.5 microM, or 148 microM of MitoVit E before, during, and after hypoxia- ischemia was not neuroprotective for striatal medium-spiny neurons. Pre- or posttreatment with 435 microM MitoVit E was neurotoxic. These results suggest that MitoVit E is not significantly neuroprotective for striatal medium-spiny neurons after acute perinatal hypoxic-ischemic brain injury. The results also suggest that mitochondrial oxidative damage does not contribute significantly to the death of striatal medium-spiny neurons after perinatal hypoxia- ischemia.
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Authors | Matthew V Covey, Michael P Murphy, Catherine E Hobbs, Robin A J Smith, Dorothy E Oorschot |
Journal | Experimental neurology
(Exp Neurol)
Vol. 199
Issue 2
Pg. 513-9
(Jun 2006)
ISSN: 0014-4886 [Print] United States |
PMID | 16480978
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Animals
- Animals, Newborn
- Antioxidants
(pharmacology, therapeutic use)
- Corpus Striatum
(drug effects, pathology)
- Dose-Response Relationship, Drug
- Female
- Hypoxia-Ischemia, Brain
(drug therapy, pathology)
- Male
- Pregnancy
- Rats
- Rats, Sprague-Dawley
- Stereotaxic Techniques
- Vitamin E
(pharmacology, therapeutic use)
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