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Effect of the mitochondrial antioxidant, Mito Vitamin E, on hypoxic-ischemic striatal injury in neonatal rats: a dose-response and stereological study.

Abstract
A mitochondria-targeted antioxidant, Mito Vitamin E (MitoVit E), has previously been shown to prevent mitochondrial oxidative damage. The aim of this study was to investigate the effect of MitoVit E on neuronal survival in the rat striatum after acute perinatal hypoxia-ischemia. Continuous striatal infusion with 4.35 microM, 43.5 microM, or 148 microM of MitoVit E before, during, and after hypoxia-ischemia was not neuroprotective for striatal medium-spiny neurons. Pre- or posttreatment with 435 microM MitoVit E was neurotoxic. These results suggest that MitoVit E is not significantly neuroprotective for striatal medium-spiny neurons after acute perinatal hypoxic-ischemic brain injury. The results also suggest that mitochondrial oxidative damage does not contribute significantly to the death of striatal medium-spiny neurons after perinatal hypoxia-ischemia.
AuthorsMatthew V Covey, Michael P Murphy, Catherine E Hobbs, Robin A J Smith, Dorothy E Oorschot
JournalExperimental neurology (Exp Neurol) Vol. 199 Issue 2 Pg. 513-9 (Jun 2006) ISSN: 0014-4886 [Print] United States
PMID16480978 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antioxidants
  • Vitamin E
Topics
  • Animals
  • Animals, Newborn
  • Antioxidants (pharmacology, therapeutic use)
  • Corpus Striatum (drug effects, pathology)
  • Dose-Response Relationship, Drug
  • Female
  • Hypoxia-Ischemia, Brain (drug therapy, pathology)
  • Male
  • Pregnancy
  • Rats
  • Rats, Sprague-Dawley
  • Stereotaxic Techniques
  • Vitamin E (pharmacology, therapeutic use)

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