Abstract | BACKGROUND: OBJECTIVES: METHODS: RESULTS: Significantly increased levels of GSH, GPx, GR and AA and significantly decreased activity of SOD were observed in tumor tissue (p < 0.001) and in tumor-free tissue of oral cancer patients as compared with healthy subjects. In contrast, decrease in antioxidants (GSH, GPx, GR and AA p < 0.001, SOD p < 0.05 respectively) was observed in the blood of oral cancer patients, as compared with healthy subjects. CONCLUSION: The low levels of antioxidants in the blood of oral cancer patients may be due to their increased utilization to scavenge lipid peroxides as well as their sequestration by tumor cells. The enhanced antioxidant capacities in tumor tissues can make them less susceptible to oxidative stress, conferring a selective growth advantage on tumor cells. These finding suggest that normalization of the levels of these antioxidants might be used to reduce oral tumor malignancy.
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Authors | A I Fiaschi, A Cozzolino, G Ruggiero, G Giorgi |
Journal | European review for medical and pharmacological sciences
(Eur Rev Med Pharmacol Sci)
2005 Nov-Dec
Vol. 9
Issue 6
Pg. 361-7
ISSN: 1128-3602 [Print] Italy |
PMID | 16479741
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antioxidants
- Vitamins
- Glutathione Peroxidase
- Superoxide Dismutase
- Glutathione Reductase
- Glutathione
- Ascorbic Acid
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Topics |
- Adolescent
- Adult
- Aged
- Antioxidants
(metabolism)
- Ascorbic Acid
(blood)
- Carcinoma, Squamous Cell
(blood, pathology)
- Female
- Glutathione
(blood)
- Glutathione Peroxidase
(blood)
- Glutathione Reductase
(blood)
- Humans
- Male
- Middle Aged
- Mouth Neoplasms
(blood, pathology)
- Superoxide Dismutase
(blood)
- Vitamins
(blood)
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