Alabaster skin after CO2 laser resurfacing: evidence for suppressed melanogenesis rather than just melanocyte destruction.

Abstract	Hypopigmentation is a recognized side effect of CO2 laser resurfacing. Pigment abnormalities are a major side effect of facial laser procedures and can cause much emotional distress. We report a case of a patient who, after receiving laser treatment, developed persistent hypopigmentation that has defied a variety of treatment attempts. Results of histologic and immunohistochemical studies support the hypothesis that suppressed melanogenesis rather than just destruction of melanocytes is important in the etiology of the alabaster skin side effect.
Authors	Thomas N Helm, Samuel Shatkin Jr
Journal	Cutis (Cutis) Vol. 77 Issue 1 Pg. 15-7 (Jan 2006) ISSN: 0011-4162 [Print] United States
PMID	16475489 (Publication Type: Case Reports, Journal Article)
Chemical References	Antigens, Neoplasm MART-1 Antigen MLANA protein, human Neoplasm Proteins Carbon Dioxide
Topics	Antigens, Neoplasm Carbon Dioxide (adverse effects) Humans Hypopigmentation (etiology, pathology) Lasers (adverse effects) MART-1 Antigen Male Melanocytes (pathology, radiation effects) Middle Aged Neoplasm Proteins (analysis, radiation effects) Photosensitivity Disorders (radiotherapy) Skin (chemistry, pathology, radiation effects)

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