Evaluation of the effect of drugs on the cyst form of Toxoplasma gondii.

Abstract

The cyst form of Toxoplasma gondii has been implicated as a cause of recrudescence of the latent infection in congenitally infected patients and in the immunocompromised host. A method was developed to evaluate the effect of drugs on the cyst form of the parasite and used to evaluate a variety of therapeutic agents. The most active compounds against the cyst form in vitro were arprinocid-N-oxide, azithromycin, and the hydroxynaphthoquinone 566C80.

• Authors: J Huskinson-Mark, F G Araujo, J S Remington
• Journal: The Journal of infectious diseases (J Infect Dis) Vol. 164 Issue 1 Pg. 170-1 (Jul 1991) ISSN: 0022-1899 [Print] United States
• PMID: 1647421 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Anti-Infective Agents
• Coccidiostats
• Naphthoquinones
• Sulfadiazine
• Clindamycin
• arprinocid-N-oxide
• Erythromycin
• Azithromycin
• Adenine
• Fluorouracil
• Atovaquone
• Pyrimethamine

Topics

• Adenine (analogs & derivatives, pharmacology)
• Animals
• Anti-Infective Agents (pharmacology)
• Atovaquone
• Azithromycin
• Brain (parasitology)
• Clindamycin (pharmacology)
• Coccidiostats (pharmacology)
• Erythromycin (analogs & derivatives, pharmacology)
• Fluorouracil (pharmacology)
• Mice
• Mice, Inbred CBA
• Naphthoquinones (pharmacology)
• Pyrimethamine (pharmacology)
• Sulfadiazine (pharmacology)
• Toxoplasma (drug effects)