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Ether à go-go potassium channels and cancer.

Abstract
Ion channels play important roles in health and disease. In the last few years, an interesting relationship between potassium channels and cancer has evolved. Especially, members of the ether à go-go (EAG) potassium channels family have gained interest as research tools for detection and therapy of different cancers. This review will summarize most of the findings relating EAG channels and cancer, focusing on mRNA expression in tissues, oncogenic properties, modulation and pharmacology. Plausible scenarios on the cellular mechanisms of EAG oncogenicity will be discussed.
AuthorsJavier Camacho
JournalCancer letters (Cancer Lett) Vol. 233 Issue 1 Pg. 1-9 (Feb 20 2006) ISSN: 0304-3835 [Print] Ireland
PMID16473665 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
Chemical References
  • Ether-A-Go-Go Potassium Channels
Topics
  • Animals
  • Cell Cycle
  • Ether-A-Go-Go Potassium Channels (genetics, physiology)
  • Humans
  • Neoplasms (etiology, metabolism, pathology)

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