Beneficial effects of perospirone on aggressive behavior associated with dementia.

Abstract

The aim of this study was to assess the efficacy of the serotonin-dopamine antagonist perospirone in treating aggressive and agitated behavior in patients with dementia. Six patients were referred to the outpatient clinic of Ishizaki Hospital and were followed for 6 weeks. Their psychiatric diagnoses were made using the DSM-IV. Their behavioral symptoms and degrees of cognitive impairment were measured using the Behavioral Pathology in Alzheimer's Disease (BEHAVE-AD) and the Mini-Mental Examination State. The changes in BEHAVE-AD scores were investigated. Maximum benefit was achieved at a mean perospirone dose of 9.0 mg/day. No patient experienced severe adverse effects. Post-hoc analysis showed significant improvement in the total BEHAVE-AD and aggressiveness subscale scores within 2 weeks. This study suggests that perospirone is effective in improving aggressive and agitated behavioral symptoms in demented patients and is safe to use in elderly patients.

• Authors: Shinji Sato, Katsuyoshi Mizukami, Kazuo Moro, Yoshiro Tanaka, Takashi Asada
• Journal: Psychiatry and clinical neurosciences (Psychiatry Clin Neurosci) Vol. 60 Issue 1 Pg. 106-9 (Feb 2006) ISSN: 1323-1316 [Print] Australia
• PMID: 16472367 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antipsychotic Agents
• Indoles
• Isoindoles
• Thiazoles
• perospirone

Topics

• Aged
• Aged, 80 and over
• Alzheimer Disease (diagnosis, drug therapy, psychology)
• Antipsychotic Agents (adverse effects, therapeutic use)
• Dementia, Vascular (diagnosis, drug therapy, psychology)
• Dose-Response Relationship, Drug
• Female
• Follow-Up Studies
• Humans
• Indoles (adverse effects, therapeutic use)
• Isoindoles
• Mental Status Schedule
• Psychomotor Agitation (diagnosis, drug therapy, psychology)
• Thiazoles (adverse effects, therapeutic use)
• Treatment Outcome