A case of extensive linear porokeratosis with evaluation of topical tretinoin versus 5-flourouracil as treatment modalities.

Abstract

A 19-year-old male presented with linear raised lesions over extensive areas of his body that followed Blaschko's lines. The lesions were asymptomatic with ridged borders. Histopathology confirmed a diagnosis of porokeratosis. He was given topical tretinoin and topical flourouracil for local application on specified areas. The cosmetic acceptability and the safety profile of tretinoin were found to be better than those of flourouracil. However, both the agents were equally efficacious. A rare case of extensive porokeratosis with comparative evaluation of two treatment modalities is hereby presented.

• Authors: Chander Grover, Alka Goel, Soni Nanda, Nita Khurana, Belum Siva Nagi Reddy
• Journal: The Journal of dermatology (J Dermatol) Vol. 32 Issue 12 Pg. 1000-4 (Dec 2005) ISSN: 0385-2407 [Print] England
• PMID: 16471466 (Publication Type: Case Reports, Comparative Study, Journal Article)

Chemical References

• Tretinoin
• Fluorouracil

Topics

• Administration, Topical
• Adult
• Biopsy, Needle
• Dose-Response Relationship, Drug
• Drug Administration Schedule
• Evaluation Studies as Topic
• Fluorouracil (therapeutic use)
• Follow-Up Studies
• Humans
• Immunohistochemistry
• Male
• Porokeratosis (diagnosis, drug therapy, pathology)
• Risk Assessment
• Severity of Illness Index
• Treatment Outcome
• Tretinoin (therapeutic use)