Abstract | BACKGROUND: The thrombin-generation assay has a variety of clinical uses, including diagnosis of thromboembolism-related disease, and particular profiles are associated with thrombophilic risk factors. The aim of this study was to evaluate the use of this assay in screening and identifying patients who require specific thrombophilic testing. METHODS: We used a 2-step approach to perform specific thrombophilic testing and thrombin-generation assays on 169 consecutive patients. The first step was to identify particular profiles of thrombin generation corresponding to each type of thrombophilic risk factor and to determine the pertinent variables related to thrombin generation. We then performed ROC curve analysis for each predefined variable to determine the relevant cutoffs for identification of patients in need of further testing (negative predictive value, 100%). RESULTS: CONCLUSION:
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Authors | Nathalie Hézard, Lobna Bouaziz-Borgi, Marie-Geneviève Remy, Philippe Nguyen |
Journal | Clinical chemistry
(Clin Chem)
Vol. 52
Issue 4
Pg. 665-70
(Apr 2006)
ISSN: 0009-9147 [Print] England |
PMID | 16469858
(Publication Type: Journal Article)
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Chemical References |
- factor V Leiden
- Factor V
- Prothrombin
- Thrombin
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Topics |
- Adult
- Factor V
(genetics)
- Female
- Humans
- Male
- Mass Screening
- Mutation
- Polymorphism, Single Nucleotide
- Protein S Deficiency
(blood, diagnosis)
- Prothrombin
(genetics)
- ROC Curve
- Risk Factors
- Thrombin
(biosynthesis)
- Thrombophilia
(diagnosis, prevention & control)
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