Abstract | BACKGROUND: METHODS: Male Wistar rats, 250-300 g, underwent 30 min occlusion of the left anterior descending coronary artery followed by 30 min reperfusion. Immediately prior to both ischemia and reperfusion, animals received an intravenous bolus of FDP or saline control. After 30 min reperfusion, myocardial function was evaluated with a left ventricular intracavitary pressure/volume conductance microcatheter. For bioenergetics studies, myocardium was isolated at 5 min of ischemia and assayed for ATP levels. RESULTS: Compared to controls (n=8), FDP animals (n=8) demonstrated significantly improved maximal left ventricular pressure (100.5+/-5.4 mmHg versus 69.1+/-1.9 mmHg; p<0.0005), dP/dt (5296+/-531 mmHg/s versus 2940+/-175 mmHg/s; p<0.0028), ejection fraction (29.1+/-1.7% versus 20.4+/-1.4%; p<0.0017), and preload adjusted maximal power (59.3+/-5.0 mW/microL(2) versus 44.4+/-4.6 mW/microL(2); p<0.0477). Additionally, significantly enhanced ATP levels were observed in FDP animals (n=5) compared to controls (n=5) (535+/-156 nmol/g ischemic tissue versus 160+/-9.0 nmol/g ischemic tissue; p<0.0369). CONCLUSIONS:
|
Authors | Jeffrey E Cohen, Pavan Atluri, Matthew D Taylor, Todd J Grand, George P Liao, Corinna M Panlilio, Erik E Suarez, Suzanne E Zentko, Vivian M Hsu, Mark F Berry, Maximillian J Smith, Timothy J Gardner, H Lee Sweeney, Y Joseph Woo |
Journal | Heart, lung & circulation
(Heart Lung Circ)
Vol. 15
Issue 2
Pg. 119-23
(Apr 2006)
ISSN: 1443-9506 [Print] Australia |
PMID | 16469539
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
|
Chemical References |
- Anti-Arrhythmia Agents
- Cardiovascular Agents
- Fructosediphosphates
- Adenosine Triphosphate
- Phosphofructokinase-1
- 1-phosphofructokinase
- fructose-1,6-diphosphate
|
Topics |
- Adenosine Triphosphate
(metabolism)
- Animals
- Anti-Arrhythmia Agents
(administration & dosage, metabolism)
- Cardiovascular Agents
(administration & dosage, metabolism)
- Fructosediphosphates
(administration & dosage, metabolism)
- Glycolysis
(drug effects)
- Injections, Intravenous
- Male
- Models, Animal
- Myocardial Ischemia
(complications, enzymology)
- Myocardial Reperfusion Injury
(complications, drug therapy, enzymology)
- Phosphofructokinase-1
(biosynthesis, drug effects, metabolism)
- Rats
- Rats, Wistar
- Ventricular Dysfunction, Left
(drug therapy, enzymology, etiology)
|