Abstract | OBJECTIVE: RESULTS: The rats in SAP group had higher levels of serum IL-6, TNF-alpha and TChE and lower levels of serum ChAT than those in control group (P < 0.05). The serum IL-6 was positively correlated with TChE (r = 0.95, P = 0.000) and negatively correlated with ChAT (r = -0.91, P = 0.000). The TNF-alpha was also positively correlated with TChE (r = 0.93, P = 0.000) and negatively correlated with ChAT (r = -0.95, P = 0.004). The rats in CQCQD-treated group had lower levels of serum IL-6, TNF-alpha and TChE and higher levels of serum ChAT than those in SAP group (P < 0.01). The increase of white blood cell, alanine aminotransferase, aspartate aminotransferase and lactate dehydrogenase was observed in the control group first and followed by the CQCQD-treated group and SAP group sequentially (P < 0.05). Conclusions Cholinergic anti-inflammatory pathway plays an important role in the pathological changes of SAP in rats. CQCQD can relieve the systemic inflammatory response syndrome and reduce the functional damage of organs through interference on the cholinergic antiinflammatory pathway. More studies are needed to reveal the mechanism of such impact.
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Authors | Ping Xue, Zong-wen Huang, Hong-yan Zhang, Qing Xia, Yong-hong Li, Zhong-chao Wang, Zhen You, Jia Guo |
Journal | Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition
(Sichuan Da Xue Xue Bao Yi Xue Ban)
Vol. 37
Issue 1
Pg. 66-8
(Jan 2006)
ISSN: 1672-173X [Print] China |
PMID | 16468645
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Anti-Inflammatory Agents
- Chai Qin Cheng Qi decoction
- Drugs, Chinese Herbal
- Interleukin-6
- Tumor Necrosis Factor-alpha
- Choline O-Acetyltransferase
- Cholinesterases
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Topics |
- Animals
- Anti-Inflammatory Agents
(therapeutic use)
- Choline O-Acetyltransferase
(metabolism)
- Cholinesterases
(metabolism)
- Drugs, Chinese Herbal
(therapeutic use)
- Female
- Interleukin-6
(metabolism)
- Male
- Pancreatitis, Acute Necrotizing
(drug therapy, metabolism)
- Phytotherapy
- Random Allocation
- Rats
- Rats, Sprague-Dawley
- Systemic Inflammatory Response Syndrome
(metabolism, prevention & control)
- Tumor Necrosis Factor-alpha
(metabolism)
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