Hyaluronic acid-carboxycellulose membrane (Seprafilm) reduces early postoperative small bowel obstruction in gastrointestinal surgery.

Abstract

This study aimed to evaluate the efficacy of sodium hyaluronate and carboxymethylcellulose membrane (Seprafilm) on early postoperative small bowel obstruction (EPSBO). It also examined whether using Seprafilm affected surgical site infection rates in gastrointestinal surgery. One hundred eighty-four patients who had Seprafilm placed during gastrointestinal surgery between October 2000 and December 2003 were included in the study (Seprafilm group) and were compared with a matched cohort (control group) of patients operated on without Seprafilm. All patients were retrospectively assessed for EPSBO and surgical site infections. The incidence of EPSBO was significantly lower (P < 0.05) in the Seprafilm group (12/184) than in the control group (26/183). The incidence of surgical site infection between the Seprafilm (15.2%) and control (13.7%) groups was not statistically significant. The placement of Seprafilm helped to prevent EPSBO and had no significant adverse affect on surgical site infections.

• Authors: Yasuhiko Mohri, Keiichi Uchida, Toshimitu Araki, Yasuhiro Inoue, Hitoshi Tonouchi, Chikao Miki, Masato Kusunoki
• Journal: The American surgeon (Am Surg) Vol. 71 Issue 10 Pg. 861-3 (Oct 2005) ISSN: 0003-1348 [Print] United States
• PMID: 16468536 (Publication Type: Journal Article)

Chemical References

• Biocompatible Materials
• Seprafilm
• Hyaluronic Acid

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Biocompatible Materials (administration & dosage, adverse effects)
• Digestive System Surgical Procedures (adverse effects)
• Female
• Humans
• Hyaluronic Acid (administration & dosage, adverse effects)
• Intestinal Obstruction (etiology, prevention & control)
• Intestine, Small
• Male
• Middle Aged
• Retrospective Studies
• Surgical Wound Infection (etiology)
• Treatment Outcome