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Clinical experience with the effectiveness and tolerability of hylan G-F 20 in 1047 patients with osteoarthritis of the knee.

Abstract
This retrospective review evaluates the effectiveness and tolerability of hylan G-F 20 for relief of pain due to knee osteoarthritis in a large orthopedic practice over a 5-year period. Prospectively collected data from patients who initiated intra-articular hylan G-F 20 (3 weekly injections) for osteoarthritis knee pain treatment were analyzed. Efficacy variables included physician visual analogue scale (VAS: 100 mm), and patient rating of pain, mobility, and amount of pain medication taken after treatment. Patients (n=1047; 1489 knees) were an average age of 65.3 years, 60% female, and 71% had radiologic osteoarthritis grade IV. Mean VAS scores significantly improved with hylan G-F 20 compared to baseline at all time points (P<.0001). Most knees (62%-89%) responded positively with hylan G-F 20. Pain and mobility improved and less pain medication was needed after therapy. The incidences of local adverse events were 5.2% per patient and 1.2% per injection; most local adverse events were mild or moderate, with severe local events in 0.3% of injections. Our clinical experience shows that hylan G-F 20 effectively relieves osteoarthritis knee pain (as indicated) and reduces pain medication needed for up to 6 months with a low incidence of local adverse events.
AuthorsDavid D Waddell, DeWayne C Bricker
JournalThe journal of knee surgery (J Knee Surg) Vol. 19 Issue 1 Pg. 19-27 (Jan 2006) ISSN: 1538-8506 [Print] United States
PMID16468490 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Adjuvants, Immunologic
  • hylan
  • Hyaluronic Acid
Topics
  • Adjuvants, Immunologic (therapeutic use)
  • Aged
  • Female
  • Humans
  • Hyaluronic Acid (analogs & derivatives, therapeutic use)
  • Injections, Intra-Articular
  • Male
  • Osteoarthritis, Knee (drug therapy)
  • Pain Measurement
  • Prospective Studies
  • Retrospective Studies
  • Severity of Illness Index
  • Treatment Outcome

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