Susceptibility of a rodent-adapted strain of Trypanosoma vivax to Berenil, Samorin and Novidium.

The susceptibility of a rodent-adapted strain of Trypanosoma vivax (Leeflant strain Y58) to Berenil, Samorin and Novidium was tested in mice. When infected mice were treated on the second day of detectable parasitaemia, there was complete cure with Berenil at 10 mg/kg, Novidium at 4 mg/kg and Samorin at 0.2 mg/kg body weight respectively. Berenil and Novodium at lower doses rendered the mice aparasitaemic for a few days followed by heavy parasitaemia (relapse) and death. Lower doses of Samorin, on the other hand, were curative for none or only some of the mice but without relapses. These observations are related to the accepted modes of action of these drugs and their use in the field.
AuthorsR O Arowolo, B O Ikede
JournalActa tropica (Acta Trop) Vol. 34 Issue 1 Pg. 61-4 (Mar 1977) ISSN: 0001-706X [Print] SWITZERLAND
PMID16467 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Amidines
  • Benzamidines
  • Phenanthridines
  • Ethidium
  • Diminazene
  • Amidines (therapeutic use)
  • Animals
  • Benzamidines (therapeutic use)
  • Diminazene (therapeutic use)
  • Ethidium (therapeutic use)
  • Mice
  • Phenanthridines (therapeutic use)
  • Trypanosoma
  • Trypanosomiasis (drug therapy, parasitology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: