Abstract | OBJECTIVE: To study the relationship between the polymorphism of ApoE gene and TCM syndrome type of primary hyperlipemia. METHODS:
ApoE genotype of 102 patients with hyperlipemia was detected by gene PCR sequencing. RESULTS: A total of five genotypes were detectable, they were E2/2, E3/3, E4/4, E2/3 and E3/4. The frequency of E3/4 + E4/4 and epsilon4 allelotype detected in the patients of Gan-Shen Yin deficiency syndrome type were significantly higher than those in patients of Pi-Shen Yang-deficiency type or of phlegm stagnation type (P < 0.05, P < 0.01), and which in patients of Qi-stagnation caused blood stasis type were significantly higher than those in patients of phlegm stagnation type ( P < 0.05). CONCLUSION: Polymorphism of ApoE gene is related in a certain degree to TCM syndrome type of primary hyperlipemia.
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Authors | Wei-Min Jiang, Shu-Hua Tang, Ren-Sheng Lai |
Journal | Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine
(Zhongguo Zhong Xi Yi Jie He Za Zhi)
Vol. 26
Issue 1
Pg. 38-41
(Jan 2006)
ISSN: 1003-5370 [Print] China |
PMID | 16466170
(Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Apolipoproteins E
(genetics)
- Diagnosis, Differential
- Female
- Genotype
- Humans
- Hyperlipidemias
(diagnosis, genetics)
- Male
- Medicine, Chinese Traditional
- Middle Aged
- Polymorphism, Genetic
- Yin Deficiency
(genetics)
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