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[Study on the relationship between polymorphism of ApoE gene and TCM syndrome type of primary hyperlipemia].

AbstractOBJECTIVE:
To study the relationship between the polymorphism of ApoE gene and TCM syndrome type of primary hyperlipemia.
METHODS:
ApoE genotype of 102 patients with hyperlipemia was detected by gene PCR sequencing.
RESULTS:
A total of five genotypes were detectable, they were E2/2, E3/3, E4/4, E2/3 and E3/4. The frequency of E3/4 + E4/4 and epsilon4 allelotype detected in the patients of Gan-Shen Yin deficiency syndrome type were significantly higher than those in patients of Pi-Shen Yang-deficiency type or of phlegm stagnation type (P < 0.05, P < 0.01), and which in patients of Qi-stagnation caused blood stasis type were significantly higher than those in patients of phlegm stagnation type ( P < 0.05).
CONCLUSION:
Polymorphism of ApoE gene is related in a certain degree to TCM syndrome type of primary hyperlipemia.
AuthorsWei-Min Jiang, Shu-Hua Tang, Ren-Sheng Lai
JournalZhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine (Zhongguo Zhong Xi Yi Jie He Za Zhi) Vol. 26 Issue 1 Pg. 38-41 (Jan 2006) ISSN: 1003-5370 [Print] China
PMID16466170 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Apolipoproteins E
Topics
  • Adult
  • Aged
  • Aged, 80 and over
  • Apolipoproteins E (genetics)
  • Diagnosis, Differential
  • Female
  • Genotype
  • Humans
  • Hyperlipidemias (diagnosis, genetics)
  • Male
  • Medicine, Chinese Traditional
  • Middle Aged
  • Polymorphism, Genetic
  • Yin Deficiency (genetics)

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