[Management of cutaneous leishmaniasis in adults and children].

Abstract

Cutaneous leishmaniasis can present a variety of clinical features and courses. The causative Leishmania species is an important prognostic factor in immunocompetent patients. Local treatment modalities including topical paromomycin, cryotherapy, localized controlled heat, carbon dioxide laser therapy, or intralesional meglumine antimoniate can be effective against Leishmania major or Leishmania tropica. Oral fluconazole may be a second-line treatment. Parenteral antimonials are useful for persistent or recurrent Old World leishmaniasis. For New World leishmaniasis, parenteral antimonials represent the first-line treatment in all forms except those caused by Leishmania guyanensis in which pentamidine is preferable. Liposomal amphotericin B appears to be effective for treatment of cutaneous leishmaniasis but further study will be needed. Results using oral Miltefosine are promising against Indian kala-azar (Leishmania donovani) but disappointing against South American leishmaniasis.

• Authors: P Minodier, G Noël, P Blanc, M Uters, K Retornaz, J M Garnier
• Journal: Medecine tropicale : revue du Corps de sante colonial (Med Trop (Mars)) Vol. 65 Issue 5 Pg. 487-95 (Nov 2005) ISSN: 0025-682X [Print] France
• Vernacular Title: Traitement des leishmanioses cutanées de l'adulte et de l'enfant.
• PMID: 16465821 (Publication Type: English Abstract, Journal Article, Review)

Chemical References

• Antiprotozoal Agents

Topics

• Administration, Oral
• Adult
• Age Factors
• Antiprotozoal Agents (therapeutic use)
• Child
• Cryotherapy
• Humans
• Hyperthermia, Induced
• Laser Therapy
• Leishmaniasis, Cutaneous (drug therapy, pathology)
• Prognosis