The complete sequence of the group-specific antigen, VP7, of African horsesickness disease virus serotype 4 reveals a close relationship to bluetongue virus.

Abstract

The complete sequence of the S7 RNA that codes for the major group-specific coat protein. VP7, of African horsesickness virus serotype 4 (AHSV-4) was determined from cDNA analyses and found to be 1179 nucleotides in length. One single open reading frame of 353 codons was observed defining a protein of Mr 38,107 with a net charge of -1.5 at neutral pH. Comparison of the AHSV-4 VP7 sequence with that of bluetongue virus serotype 10 revealed an overall similarity of 44%, with the amino- and carboxy-terminal regions exhibiting the greatest levels of homology. In addition, potential secondary structures of the terminal sequences of the S7 RNA segments of AHSV-4 and BTV serotypes 10, 13 and 17 are presented.

• Authors: P Roy, T Hirasawa, M Fernandez, V M Blinov, J M Sanchez-Vixcain Rodrique
• Journal: The Journal of general virology (J Gen Virol) Vol. 72 ( Pt 6) Pg. 1237-41 (Jun 1991) ISSN: 0022-1317 [Print] England
• PMID: 1646273 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Antigens, Viral
• RNA, Viral
• Viral Core Proteins
• VP7 major core antigen, African horsesickness virus

Topics

• African Horse Sickness Virus (classification, genetics)
• Amino Acid Sequence
• Antigens, Viral (genetics)
• Bluetongue virus (genetics)
• Molecular Sequence Data
• Nucleic Acid Conformation
• Open Reading Frames
• Protein Conformation
• RNA, Viral (genetics)
• Sequence Homology, Nucleic Acid
• Viral Core Proteins