Abstract | PURPOSE OF REVIEW: Among the myriad of players in the calcification of cartilage, ANK is a relatively new entrant. It is a multipass transmembrane protein that regulates the transport of inorganic pyrophosphate between the cell and the extracellular space. Mutations in ANK result in two distinct calcification disorders: craniometaphyseal dysplasia and familial calcium pyrophosphate dihydrate deposition disease. The purpose of this review is to highlight recent work on the role of ANK in physiological and pathological calcification of articular and growth plate cartilage. RECENT FINDINGS: SUMMARY: Additional studies will be required to understand the contribution of ANK in shaping the fine balance of components necessary for crystal deposition in degenerating articular cartilage. Furthermore, the precise role of inherited mutations in ANK on the elaboration of inorganic pyrophosphate, and the ultimate deposition of either basic calcium phosphate or calcium pyrophosphate dihydrate crystals, remains unclear.
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Authors | Raihana Zaka, Charlene J Williams |
Journal | Current opinion in rheumatology
(Curr Opin Rheumatol)
Vol. 18
Issue 2
Pg. 181-6
(Mar 2006)
ISSN: 1040-8711 [Print] United States |
PMID | 16462526
(Publication Type: Journal Article, Review)
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Chemical References |
- ANKH protein, human
- Calcium Phosphates
- Diphosphates
- Phosphate Transport Proteins
- calcium phosphate
- Calcium Pyrophosphate
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Topics |
- Calcinosis
(genetics, metabolism, physiopathology)
- Calcium Phosphates
(metabolism)
- Calcium Pyrophosphate
(metabolism)
- Cartilage, Articular
(metabolism, pathology, physiopathology)
- Diphosphates
(metabolism)
- Genetic Predisposition to Disease
(genetics)
- Growth Plate
(metabolism, pathology, physiopathology)
- Humans
- Mutation
(genetics)
- Phosphate Transport Proteins
(genetics, metabolism)
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