Abstract | OBJECTIVES: METHODS: Male Sprague-Dawley rats received a single intraperitoneal injection of CYP (200 mg/kg). In a separate group of animals, 15d-PGJ2 (10 and 100 microg/kg intraperitoneal bolus 10 minutes before and 24 hours after CYP injection) or a selective inducible nitric oxide synthase (iNOS) inhibitor, N-(3-(aminomethyl)benzyl)acetamidine ([1400W] 10 mg/kg intraperitoneal bolus 10 minutes before and 12 and 24 hours after CYP injection), was administered. At 48 hours after CYP injection, the rats were killed, and tissues were removed for evaluation of cystitis. RESULTS: CONCLUSIONS:
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Authors | Hitoshi Masuda, Michael B Chancellor, Kazunori Kihara, Naoki Yoshimura |
Journal | Urology
(Urology)
Vol. 67
Issue 2
Pg. 435-9
(Feb 2006)
ISSN: 1527-9995 [Electronic] United States |
PMID | 16461118
(Publication Type: Journal Article)
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Chemical References |
- 15-deoxy-delta(12,14)-prostaglandin J2
- Immunologic Factors
- Interleukin-1
- Cyclophosphamide
- Nitric Oxide Synthase Type II
- Prostaglandin D2
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Topics |
- Animals
- Cyclophosphamide
(administration & dosage)
- Cystitis
(chemically induced, metabolism, prevention & control)
- Immunologic Factors
(therapeutic use)
- Interleukin-1
(biosynthesis)
- Male
- Nitric Oxide Synthase Type II
(metabolism)
- Prostaglandin D2
(analogs & derivatives, therapeutic use)
- Rats
- Rats, Sprague-Dawley
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