Abstract | OBJECTIVE: STUDY DESIGN: RESULTS: MPA and CMA with GFs induced proliferation of MCF10A cells. P, T, NET, LNG, DNG, GSD and KDG had no significant effect. In HCC1500 cells, MPA and CMA with GFs had an inhibitory effect compared to GFs alone. NET, LNG, DNG, GSD, KDG and T enhanced the proliferative effect of GFs. P had no significant effect. No progestogen could further enhance the stimulatory effect of E2 on HCC1500 cells; all but KDG inhibited it. MPA, GSD, T, CMA and NET had an anti-proliferative effect on the mitotic GF and E2 combination. P, LNG, DNG and KDG had no significant effect. CONCLUSIONS:
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Authors | Elizabeth A Krämer, Harald Seeger, Bernhard Krämer, Diethelm Wallwiener, Alfred O Mueck |
Journal | European journal of obstetrics, gynecology, and reproductive biology
(Eur J Obstet Gynecol Reprod Biol)
Vol. 129
Issue 1
Pg. 77-83
(Nov 2006)
ISSN: 0301-2115 [Print] Ireland |
PMID | 16460873
(Publication Type: Journal Article)
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Chemical References |
- Progesterone Congeners
- Fibroblast Growth Factor 2
- Testosterone
- Progesterone
- Estradiol
- Epidermal Growth Factor
- Insulin-Like Growth Factor I
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Topics |
- Breast
(cytology)
- Breast Neoplasms
(metabolism)
- Cell Death
(drug effects)
- Cell Proliferation
(drug effects)
- Cells, Cultured
- Epidermal Growth Factor
(pharmacology)
- Epithelial Cells
(drug effects)
- Estradiol
(pharmacology)
- Female
- Fibroblast Growth Factor 2
(pharmacology)
- Hormone Replacement Therapy
(adverse effects)
- Humans
- Insulin-Like Growth Factor I
(pharmacology)
- Progesterone
(pharmacology)
- Progesterone Congeners
(pharmacology)
- Testosterone
(pharmacology)
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