Abstract | BACKGROUND: METHODS: Using quantitative reverse transcription polymerase chain reaction (RT-PCR), GRalpha mRNA and GRbeta mRNA were measured in peripheral blood cells of major depressive disorder patients (depressive n = 18; remissive n = 38), bipolar disorder patients (depressive n = 13; remissive n = 35), normal control subjects (n = 31), and first-degree relatives of major depressive (n = 17) and bipolar (n = 15) disorder patients. RESULTS: CONCLUSIONS: Our results suggest that reduced GRalpha mRNA expression might be trait-dependent and associated with the pathophysiology of mood disorders.
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Authors | Toshio Matsubara, Hiromasa Funato, Ayumi Kobayashi, Masaaki Nobumoto, Yoshifumi Watanabe |
Journal | Biological psychiatry
(Biol Psychiatry)
Vol. 59
Issue 8
Pg. 689-95
(Apr 15 2006)
ISSN: 0006-3223 [Print] United States |
PMID | 16458268
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antidepressive Agents
- RNA, Messenger
- Receptors, Glucocorticoid
- glucocorticoid receptor alpha
- glucocorticoid receptor beta
- Dexamethasone
- Corticotropin-Releasing Hormone
- Hydrocortisone
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Topics |
- Adult
- Analysis of Variance
- Antidepressive Agents
(therapeutic use)
- Case-Control Studies
- Corticotropin-Releasing Hormone
(metabolism)
- Dexamethasone
(administration & dosage)
- Family Health
- Female
- Gene Expression Regulation
(physiology)
- Humans
- Hydrocortisone
(blood)
- Male
- Middle Aged
- Mood Disorders
(classification, drug therapy, genetics, physiopathology)
- RNA, Messenger
(genetics, metabolism)
- Receptors, Glucocorticoid
(genetics, metabolism)
- Recurrence
- Reverse Transcriptase Polymerase Chain Reaction
(methods)
- Statistics as Topic
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