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Effects of a manganese (III) porphyrin catalytic antioxidant in a mouse closed head injury model.

Abstract
Closed head injury induces cerebral oxidative stress. The efficacy of a Mn (III) porphyrin catalytic antioxidant was assessed in a mouse closed head injury model. Mice were subjected to closed head injury and treated 15 min later with an i.v. bolus of vehicle or 3 mg/kg MnTE-2-PyP5+. Aconitase activity, Fluoro-Jade staining, glial fibrillary acidic protein immunoreactivity, and rotarod falling latencies were measured. Closed head injury altered all variables. MnTE-2-PyP5+ had no effect on any variable with the exception of attenuation of aconitase inactivation at 2 h post-closed head injury. In a second experiment, mice received 3 mg/kg or 6 mg/kg MnTE-2-PyP5+ or vehicle i.v. 15 min post-closed head injury. Rotarod and Morris water maze latencies were measured. Closed head injury altered performance in both tests. No statistically significant effect of MnTE-2-PyP5+ was observed. We conclude that single dose MnTE-2-PyP5+ does not alter outcome in this mouse closed head injury model.
AuthorsStephen B Leinenweber, Huaxin Sheng, John R Lynch, Haichen Wang, Ines Batinić-Haberle, Daniel T Laskowitz, James D Crapo, Robert D Pearlstein, David S Warner
JournalEuropean journal of pharmacology (Eur J Pharmacol) Vol. 531 Issue 1-3 Pg. 126-32 (Feb 15 2006) ISSN: 0014-2999 [Print] Netherlands
PMID16455070 (Publication Type: Comparative Study, Journal Article, Research Support, N.I.H., Extramural)
Chemical References
  • Antioxidants
  • Glial Fibrillary Acidic Protein
  • Metalloporphyrins
  • manganese (III) meso-tetrakis(N-ethylpyridinium-2-yl)porphyrin
  • Manganese
  • Aconitate Hydratase
Topics
  • Aconitate Hydratase (metabolism)
  • Animals
  • Antioxidants (administration & dosage, chemistry, pharmacology)
  • Body Weight (drug effects)
  • Cerebral Cortex (chemistry, drug effects)
  • Dose-Response Relationship, Drug
  • Glial Fibrillary Acidic Protein (analysis)
  • Head Injuries, Closed (metabolism, physiopathology, prevention & control)
  • Immunohistochemistry
  • Injections, Intravenous
  • Male
  • Manganese (chemistry)
  • Maze Learning (drug effects)
  • Metalloporphyrins (administration & dosage, chemistry, pharmacology)
  • Mice
  • Mice, Inbred C57BL
  • Motor Activity (drug effects)
  • Rotarod Performance Test
  • Time Factors

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