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Clinical effect of BV-araU on varicella-zoster virus infection in immunocompromised patients with haematological malignancies.

Abstract
We evaluated the treatment of varicella-zoster infection with BV-araU in immuno-compromised patients with haematological malignancies in a randomized controlled study. Comparison was made between doses of 150 and 30 mg/day. For ethical reasons there was no placebo group. The percentage of patients given a 'very effective' rating by both attending physicians and the Evaluation Committee was significantly higher in the 150 mg/day group (56.0%) compared to the 30 mg/day group (15.0%). There was no significant difference in efficacy rate ('very effective' plus 'effective') between the two groups. The incidence of side effects was low (7.8%), all were mild and disappeared on stopping treatment. These results suggest that BV-araU is clinically useful, especially at a dose of 150 mg/day in immunocompromised patients. Further comparative studies between BV-araU and acyclovir or vidarabine are indicated.
AuthorsA Hiraoka, T Masaoka, K Nagai, A Horiuchi, A Kanamaru, M Niimura, T Hamada, M Takahashi
JournalThe Journal of antimicrobial chemotherapy (J Antimicrob Chemother) Vol. 27 Issue 3 Pg. 361-7 (Mar 1991) ISSN: 0305-7453 [Print] England
PMID1645332 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
Chemical References
  • Antiviral Agents
  • Arabinofuranosyluracil
  • sorivudine
Topics
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Antiviral Agents (therapeutic use)
  • Arabinofuranosyluracil (adverse effects, analogs & derivatives, therapeutic use)
  • Chickenpox (diagnosis, drug therapy)
  • Child
  • Hematologic Diseases (complications)
  • Herpesvirus 3, Human
  • Humans
  • Immune Tolerance
  • Middle Aged
  • Remission Induction

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